Renue By Science Liposomal Apigenin - 90 ct Capsules

Renue By Science Liposomal Apigenin - 90 ct Capsules

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LIPO Apigenin features our proprietary, powder-based liposomes made from natural phospholipid molecules that protect it from digestive enzymes and carry it into the bloodstream for targeted systemic delivery.

Description

Apigenin is a naturally-occurring bioactive plant polyphenol with antioxidant and anti-inflammatory properties.

Senescent Cells Increase CD38 and Decrease NAD⁺ Levels

As you age, you accumulate senescent or “zombie” cells, cells that have reached their limit of cell division and would normally be swept away and replaced by younger cells. Instead, these cells hang around and begin to secrete toxins called SASP factors which increase systemic inflammation.

The rising levels of inflammation cause an increase in an enzyme called CD38, a big consumer of NAD⁺, causing systemic NAD⁺ levels to drop.

“Our data suggest a link between cellular senescence and NAD⁺ decline in which SASP-mediated upregulation of CD38 can disrupt cellular NAD⁺ homeostasis.” (1)

Fighting Declining Levels of NAD⁺ with Apigenin

Apigenin prevents excessive loss of NAD⁺ by reducing the amount of circulating CD38, allowing NAD⁺ stores to remain at higher, more youthful levels.

We showed that the activity of CD38, but not PARP, increases in several tissues during the aging process, and that genetic ablation of CD38 protects against age-related NAD⁺ decline and, mitochondrial dysfunction.” (2)

Inhibition of CD38 Increases Lifespan and Healthspan in Mice

Studies have found that lowering CD38 levels (using a CD38 inhibitor called 78c) not only increased NAD⁺ levels but also improved mitochondrial function and endurance performance.

“Aged mice (2 years old) had lower tissue NAD⁺ levels, and worse glucose tolerance compared with younger mice. 78c promoted a significant increase in NAD⁺ levels in tissues of aged mice.” (3)

Liposomal Delivery

LIPO Apigenin uses a sustained-released liposomal delivery system that provides superior absorption in easy-to-swallow capsules.

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